Open and endoscopic approaches to the skull base are technically demanding and challenging. These procedures are employed for tumours sharing close proximity to the brain, carotid artery, cavernous sinus, parasellar region and infratemporal fossa. Transnasal , transbasal, transpalatal, transsphenoidal, are few of the approaches described. CSF leaks, meningitis, sepsis, haemorrhage , cranial nerve deficits are few of the complications following these procedures . Careful selection of cases, and meticulous handling of tissues and adequate reconstruction can help avert these complications to a great extent.